The head of the Reds was further weakened this week by a hamstring injury to Fabinho in the central defense.
Now Liverpool are back in the Premier League, with Jurgen Klopp West Ham United next to entertain the walking wounded.
A look at how Jurgen Klopp might rearrange his pack when West Ham United visit Liverpool on Saturday night
As Joel Matip continues to fight for his long-term fitness, Klopp is left with only Joe Gomez as his only older central defender.
“If someone has a muscle problem, the doctor calls me pretty rarely the next morning and says it’s a false alarm, everything is fine,” Klopp said about Fabinho’s injury.
The Brazilian midfielder, who stood in for the battered Virgil van Dijk, was sent for a check-up on Wednesday and is facing an unresolved ban on the sidelines.
Rhys Williams has performed admirably alongside Gomez against the Danes, and although he is likely to face tougher tests in the Liverpool jersey, the 19-year-old can be justly proud of his performance on Tuesday night.
Fabinho was already playing from the position when the problem occurred in the first half against FC Midtjylland.
“Rhys played really well,” Klopp said. “Now we have four days to West Ham and you’re going to write a story about him.
Despite the obvious lack of options at the moment, Klopp wanted to put on a brave face after the third hard-fought win in a row and pointed to Nat Phillips and Billy Koumetio as possible options for the central defender on Saturday night.
“He is a talent, 19 years old and has more Champions League minutes than Premier League minutes,
“We also have Nat Phillips, he’s a central defender. Billy ‘the kid’ too, he’s gonna practice this week.”
“He’s now played two Champions League games and won both. Promising.
It remains to be seen who or what Klopp will choose in defense to visit the Hammers, but there is a school of thought where captain Jordan Henderson or Gini Wijnaldum will switch to central defender.
Both midfielders have already played for the Reds there and could help Klopp out of a jam if Matip doesn’t make the cut, which is likely at this stage.
The other big question for Klopp is what he is doing with his midfield.
Will he return to his proven 4-3-3 after successive games in a 4-2-3-1 formation, largely due to a lack of fit and available central midfielders?
That might require some creativity, but it won’t be a unique situation for either of them if they get the nod in the middle half.