Already in the summer, the team reported in the English-language journal “Cannabis and Cannabinoid Research” that treatment with CBD reduces classic effects of adult respiratory distress syndrome (ARDS) such as excessive pneumonia, thereby improving lung function and repairing some of the structural lung damage. ARDS is one of the possible complications of COVID-19.
CBD appears to help prevent more serious lung damage from COVID-19, according to a study involving researchers from the Dental College of Georgia and the Medical College of Georgia. The results were published in the Journal of Cellular and Molecular Medicine.
CBD appears to protect the lungs from serious damage when COVID-19 is used to treat disease. The protective effect is probably due to the fact that CBD increases the level of a specific peptide.
Apelin levels normalized by CBD
CBD to protect the lungs in COVID-19?
Blood levels of the peptide apelin dropped almost to zero in the ARDS model and increased 20-fold due to CBD. CBD has brought Apelin almost back to normal levels, the researchers emphasize. Further research on mice with COVID symptoms has now shown that apelin levels also decrease sharply in COVID-19 and that CBD quickly helps to normalize apelin levels along with lung function.
One way that CBD appears to reduce the lung damaging cytokine storm in COVID-19 is that CBD causes an increase in levels of the natural peptide apelin. This is known to reduce inflammation and it has been shown that the levels of apelin are dramatically lowered in the face of the cytokine storm, the researchers explain.
Effects of CBD in ARDS
Apelin is a peptide produced by cells in the heart, lungs, brain, fatty tissue and blood. The peptide is an important regulator to lower both blood pressure and inflammation, explain the experts.
For example, when blood pressure is elevated, the apelin level should rise in order to lower blood pressure again. When it comes to the significant increase in inflammation in the lungs and the associated breathing difficulties associated with ARDS, Apelin could also bring this condition back to normal, according to the research group.
Although not all the benefits of CBD can be attributed to Apelin, the researchers believe that the peptide clearly plays an important role in this scenario. According to the experts, however, it remains unclear whether the novel coronavirus or CBD have a direct influence on apelin or whether these are downstream effects.
Further research is needed, including finding out how CBD caused the significant changes, and studies in humans should be conducted before CBD can be included as part of a treatment regimen for COVID-19.
Ideally, in ARDS, apelin would increase in those areas of the lung where it is needed to improve blood and oxygen flow to balance and protect, the researchers explain. In the study of ARDS, apelin did not react and instead decreased both in the lung tissue itself and in the general circulation. This changed when the researchers administered CBD.
WashingtonNewsday Health and Wellness.